Desmin 1,0 ml
Specificity and Comments:
Desmin recognizes a 53kDa intermediate filament protein which is identified
as desmin. This MAb is highly specific to desmin and shows no cross-reaction
with other intermediate filament proteins. Antibody to desmin reacts with
striated (skeletal and cardiac) as well as smooth muscle cells. In skeletal and
cardiac muscles, the staining is confined to the Z-bands giving a characteristic
striated appearance. Anti-desmin antibody is useful in identification of tumors
of myogenic origin. It reacts with leiomyosarcomas (smooth muscle) as well as
rhabdomyosarcomas (striated muscle). BIOCARE’S D33 MAb is excellent for staining
of formalin-fixed paraffin-embedded tissues.
Human, baboon, monkey, cow, cat, dog,
hamster, rat, and chicken.
Isotype: IgG1 / ?
Immunogen: Desmin purified from human muscle
Known Applications: Immunohistochemistry (formalin-fixed paraffin embedded
Positive Control: Leiomyosarcoma
Cellular Localization: Cytoplasmic
Buffer with protein carrier and preservative
Storage and Stability:
Store vial at 4°C. Stable for 18 months.