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PIN-4 Cocktail (P504S+P63+HMW) Double Stain 25 mL

Intended Use
Source ,
Species Reactivity ,
Cellular Localization ,
Positive Control
Normal Tissue
Abnormal Tissue ,

In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal epithelia, in the prostate gland.

p63 is detected in prostate basal epithelial nuclei in normal prostate, however, is negative in malignant tumors of the prostate gland. Thus p63 is useful as a differential marker for benign and malignant tumors of prostate gland and can be useful as a negative marker.

Expression of P504S protein is found in prostatic adenocarcinoma, but not in benign prostatic tissue. It has also been found to stain premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. P504S can be used as a positive marker for PIN. It will be useful to confirm the diagnosis of small focus of prostate carcinoma in needle biopsies.

The combination of P504S + HMW CKs + p63 (PIN-4™) may be extremely useful for diagnosing prostatic intraepithelial neoplasia, especially in difficult cases, and in cases with limited tissues. P504S stains cytoplasm in prostate adenocarcinoma and atypical adenomatous hyperplasia, and p63 and HMW CKs stain normal (negative marker) and benign prostate glands.

A two-component version (IVD, ASR) can also be purchased:
Prostate-2X (CK5 + CK14 + p63) Cat. No. PM 364 AAK, HK, JJK (IVD)
p504S-2X Cat. No. PP 365 AA, H, JJ (ASR)

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