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Ki-67 + Caspase-3 DS 6ml

Intended Use
Source , 
Species Reactivity , 
Antigen , 
Cellular Localization , 
Positive Control , 
Normal Tissue , 
Abnormal Tissue , 

This Multiplex IHC was designed to provide information on cell death vs. cell proliferation rates. The Ki-67 nuclear antigen is associated with cell proliferation. It is found throughout the cell cycle that includes the G1, S, G2, and M phases; but not the (GO) phase. Apoptosis is a process, in which cells activate an intrinsic suicide mechanism that destroys themselves. The proteases that mediate this execution are called capases (cysteinyl-aspartic acid proteases). Cleaved caspase-3 detects endogenous levels of the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to (Asp175). Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 subunits. Cleavage of caspase-3 requires aspartic acid at the P1 position. This antibody does not cross react with other cleaved caspases. Cleaved caspase-3 is an affinity purified rabbit polyclonal antibody. This Multiplex combination of Ki-67 and Caspase-3 has been optimized with Biocare’s Decloaking Chamber, Double Stain Detection 2 and chromogens.

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