In normal epithelia, HMW Cytokeratins (CK5 and CK14) stain basal
epithelia, in the prostate gland.
p63 is detected in prostate basal epithelial nuclei in normal
prostate, however, is negative in malignant tumors of the prostate gland. Thus
p63 is useful as a differential marker for benign and malignant tumors of
prostate gland and can be useful as a negative marker.
Expression of P504S protein is found in prostatic adenocarcinoma,
but not in benign prostatic tissue. It has also been found to stain premalignant
lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN)
and atypical adenomatous hyperplasia. P504S can be used as a positive marker for
PIN. It will be useful to confirm the diagnosis of small focus of prostate
carcinoma in needle biopsies.
The combination of P504S + HMW CKs + p63 (PIN-4™) may be extremely
useful for diagnosing prostatic intraepithelial neoplasia, especially in
difficult cases, and in cases with limited tissues. P504S stains cytoplasm in
prostate adenocarcinoma and atypical adenomatous hyperplasia, and p63 and HMW
CKs stain normal (negative marker) and benign prostate glands.
A two-component version (IVD, ASR) can also be
Prostate-2X (CK5 + CK14 + p63) Cat. No. PM 364 AAK, HK, JJK
p504S-2X Cat. No. PP 365 AA, H, JJ (ASR)